Journal of Medicinal Chemistry
Volume 41, Issue 14 (July 2, 1998)
Copyright © 1998
American Chemical Society
COMMUNICATIONS TO THE EDITOR | |
2439-2441 | 1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540): A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue
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2442-2444 | 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]- [1,4]benzodiazepin-10(11H)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985): An Orally Active Arginine Vasopressin Antagonist with Selectivity for V2 Receptors
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EXPEDITED ARTICLES | |
2445-2450 | Substituted Halogenated Arylsulfonamides: A New Class of Receptor Binding Tumor Imaging Agents
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2451-2460 | Structure-Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
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ARTICLES | |
2461-2480 | Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones
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2481-2491 | New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids
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2492-2502 | Design of a New Class of Orally Active Fibrinogen Receptor Antagonists
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2503-2512 | Pharmacophores Incorporating Numerous Excluded Volumes Defined by X-ray Crystallographic Structure in Three-Dimensional Database Searching: Application to the Thyroid Hormone Receptor
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2513-2523 | Heteroaryl Analogues of AMPA. 2. Synthesis, Absolute Stereochemistry, Photochemistry, and Structure-Activity Relationships
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2524-2536 | Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist
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2537-2552 | Synthesis and Evaluation of Analogues of the Partial Agonist 6-(Propyloxy)-4-(methoxymethyl)--carboline-3-carboxylic Acid Ethyl Ester (6-PBC) and the Full Agonist 6-(Benzyloxy)-4-(methoxymethyl)-- carboline-3-carboxylic Acid Ethyl Ester (Zk 93423) at Wild Type and Recombinant GABAA Receptors
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2553-2564 | Three-Dimensional Quantitative Similarity-Activity Relationships (3D QSiAR) from SEAL Similarity Matrices
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2565-2571 | Homonojirimycin Isomers and N-Alkylated Homonojirimycins: Structural and Conformational Basis of Inhibition of Glycosidases
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2572-2578 | Carbocyclic Analogues of the Potent Cytidine Deaminase Inhibitor 1-(-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one (Zebularine)
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2579-2587 | Synthesis and Evaluation of Peptidyl Michael Acceptors That Inactivate Human Rhinovirus 3C Protease and Inhibit Virus Replication
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2588-2603 | Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases
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2604-2613 | Neurosteroid Analogues. 6. The Synthesis and GABAA Receptor Pharmacology of Enantiomers of Dehydroepiandrosterone Sulfate, Pregnenolone Sulfate, and (3,5)-3-Hydroxypregnan-20-one Sulfate
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2614-2620 | Minimal-Size, Constrained Corticotropin-Releasing Factor Agonists with i-(i+3) Glu-Lys and Lys-Glu Bridges
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2621-2625 | Synthesis of 7,8-(Methylenedioxy)-1-phenyl-3,5-dihydro-4H-2,3-benzodiazepin- 4-ones as Novel and Potent Noncompetitive AMPA Receptor Antagonists
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NOTES | |
2626-2630 | In Vitro Platelet-Activating Factor Receptor Binding Inhibitory Activity of Pinusolide Derivatives: A Structure-Activity Study
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2631-2635 | Synthesis and Biological Activity of a Novel Methylamine-Bridged Enkephalin Analogue (MABE): A New Route to Cyclic Peptides and Peptidomimetics
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2636-2642 | Nitroaromatic Amino Acids as Inhibitors of Neuronal Nitric Oxide Synthase
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2643-2650 | Identification of a Dihydropyridine as a Potent 1a Adrenoceptor-Selective Antagonist That Inhibits Phenylephrine-Induced Contraction of the Human Prostate
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2651-2656 | N-Arylalkyl Pseudopeptide Inhibitors of Farnesyltransferase
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2657-2660 | 14-Desoxy Analogues of Naltrindole and 7-Spiroindanyloxymorphone: The Role of the 14-Hydroxy Group at Opioid Receptors
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BOOK REVIEWS | |
2661-2661 | Oxford Dictionary of Biochemistry and Molecular Biology Edited by A. D. Smith, S. P. Datta, G. H. Smith, P. N. Campbell, R. Bentley, and H. A. McKenzie. Oxford University Press, Oxford. 1997. xi + pp. 20.5 x 26 cm. ISBN 0-19-854768-4. $60.00.
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2661-2661 | Affinity Separations. A Practical Approach Edited by Paul Matejtschuk. Oxford University Press, New York. 1997. xix + 253 pp. 15.5 x 23.5 cm. ISBN 0-19-963550-1. $55.00.
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2661-2662 | The Impact of Stereochemistry on Drug Development and Use Edited by Hassan Y. Aboul-Enein and Irving W. Wainer. John Wiley & Sons, New York. 1997. xxvii + 695 pp. 16 x 24 cm. ISBN 0471596442. $99.00.
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